| ncRNA name | EMMPRIN siRNA |
| ncRNA Category | siRNA |
| Disease name | Pseudomonas aeruginosa keratitis |
| Species | Mus musculus |
| Tissues/Cell_line | corneas |
| Methods | siRNA injection, qPCR, cytokines assay, Western blot |
| Expression pattern | associated |
| Functional description | EMMPRIN promotes host resistance against pseudomonas aeruginosa infection via MAPK signaling pathway. Silence of EMMPRIN Enhanced the Production of pro-inflammatory cytokines in PA keratitis. Silence of EMMPRIN significantly up-regulated Th1-type cytokines IFN-γ, IL-12, and IL-18, but down-regulated Th2-type cytokines IL-4, IL-5, and IL-10. |
| PubMed ID | 28078032 |
| Year | 2016 |
| Title | Extracellular matrix metalloproteinase inducer enhances host resistance against pseudomonas aeruginosa infection through MAPK signaling pathway. |
| Drug-related ncRNA | NO |
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